Alcoholic Neuropathy: Causes, Symptoms, & Treatments

Deficiency of vitamins other than thiamine may also contribute to clinical features of alcoholic neuropathy. Chronic alcoholism can alter the intake, absorption and utilization of various nutrients (nicotinic acid, vitamin B2, vitamin B6, vitamin B12, folate or vitamin E). Thus, these vitamin deficiencies were not considered to be major causal factors of neuropathy [26].

Oxidative-nitrosative stress and alcoholic neuropathy

It has previously been considered in relationship to nutritional, especially thiamine, deficiencies seen in alcoholics. Thiamine deficiency is closely related to chronic alcoholism and can induce neuropathy in alcoholic patients. Ethanol diminishes thiamine absorption in the intestine, reduces hepatic stores of thiamine and affects the phosphorylation of thiamine, which converts it to its active form [12].

• It’s key to find a treatment center equipped to address co-occurring disorders, manage symptoms effectively, and provide tailored care for alcohol use disorder, ensuring a comprehensive and supportive approach to your well-being.
• Nine studies reported EMG findings in alcohol-related peripheral neuropathy patients.
• Symptoms may include numbness and tingling in the limbs, muscle weakness, and loss of mobility.
• In a 2019 article, researchers explain that breaking down alcohol in the body produces a chemical that damages axons.

Risk Factors and Causes of Neuropathy

Activation of spinal cord microglia, mGlu5 spinal cord receptors, and hypothalamic-pituitary-adrenal axis appear to be implicated in this process [92,93,94,95,96,97]. Oxidative stress also leads to the indirect damage of nerve fibers via the release of free radicals and proinflammatory cytokines with protein kinase C and ERK kinase phosphorylation [98,99,100,101]. Besides, ALN is characterized by insulin and insulin-like growth factor (IGF) resistance, which results in impaired trophic factor signaling [102, 103]. Alcohol use leaves no one immune to nerve damage and other health-related issues. If you or someone you know struggles with alcohol use and addiction, the best way to prevent neuropathy is to seek professional treatment. Alcohol can also cause depletion of some important nutrients, leading to deficiencies.

Alcoholic Polyneuropathy: Causes, Symptoms, And Treatment

It is still unclear what is the major determinant in the pathogenesis of ALN. Primarily, thiamine deficiency is the crucial risk factor of ALN since it induces the progression of Korsakoff’s syndrome and beriberi [144, 145]. Due to similar histologic and electrophysiological symptoms, it was believed that ALN may make up a subtype of beriberi [146]. Further research has confirmed the role of thiamine in the pathogenesis of ALN—the well-balanced diet and vitamin B1 supplementation significantly decreased the severity of ALN symptoms [147, 148]. However, the limitations of those studies include the lack of the possibility to measure the amount of vitamin B1 in the serum; further, patients who were involved in the study have received an unrefined form of the supplement.

Alcoholic neuropathy refers to nerve damage resulting from chronic heavy alcohol use. Symptoms may include numbness and tingling in the limbs, muscle weakness, and loss of mobility. A doctor may diagnose a person with alcoholic neuropathy, if alcohol use has damaged the peripheral nerves. People who alcohol neuropathy drink heavily on a regular basis are at risk of developing this condition. Treatment involves reducing or eliminating alcohol intake to prevent further nerve damage and managing symptoms through medications, physical therapy, nutritional supplements, and lifestyle changes like diet and exercise.

• With the right approach and support, we can achieve significant improvements in our symptoms and quality of life.
• Alcohol-related neurologic disease refers to a range of conditions caused by alcohol intake that affect the nerves and nervous system.

Involvement of the sympatho-adrenal and hypothalamo-pituitary-adrenal (HPA) axis in alcoholic peripheral neuropathy

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